Saffron  >  clinical studies links
 

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Antidepressant Effect of Crocus sativus: an Evidence Based..

 

Archive of SID Volume 9, Supplement No. 6, Winter 2010 Journal of Medicinal Plants

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Safety Evaluation of Saffron

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Saffron (Crocus sativus) - Health Portal

 

Saffron (Crocus sativus) ... This information is based on a systematic review of scientific ... Natural Standard developed the above evidence-based information ...

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Crocus sativus L. (saffron) in the treatment of premenstrual syndrome

 

Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial
M Agha-Hosseini,a L Kashani,b A Aleyaseen

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Ghoreishi,c H Rahmanpour,d AR Zarrinara,e S Akhondzadehf

 

Comparison-of-Crocus-sativus-L.-and-imipramine-in-the-treatment-of-mild-to-moderate-depression

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Cardioprotective Effect of Saffron Extract and Safrana ?

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Crocus Sativus L. (Saffron) Extract and its Active ...

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TJEAS - Concentration of crocin, picrocrocin and ?

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Crocin, safranal and picrocrocin from saffron Crocus ...

 

Extracts of saffron (Crocus sativus L.) have been reported to inhibit cell growth of human tumor cells. In order to study the cytotoxic effect of the characteristic compounds of saffron spice, we have isolated crocin, crocetin, picrocrocin and safranal. Doses inducing 50% cell growth inhibition (LD50) on HeLa cells were 2.3 mg/ml for an ethanolic extract of saffron dry stigmas, 3 mM for crocin, 0.8 mM for safranal and 3 mM for picrocrocin. Crocetin did not show cytotoxic effect. Cells treated with crocin exhibited wide cytoplasmic vacuole-like areas, reduced cytoplasm, cell shrinkage and pyknotic nuclei, suggesting apoptosis induction. Considering its water-solubility and high inhibitory growth effect, crocin is the more promising saffron compound to be assayed as a cancer therapeutic agent.
Revue / Journal Title
Cancer letters    ISSN  0304-3835   CODEN CALEDQ 
Source / Source
1996, vol. 100, pp. 23-30 (28 ref.)

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Crocus sativus L. (Saffron) Extract and its Active ...

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Affron Antidepressant Effect of Crocus sativus review

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Affron Comparison of Crocus sativus and imipramine

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Affron Crocus-Sativus vs fluoxetine (Prozac)

 

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Crocus sativus L in the treatment of PMS

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Saffron and alzheimer clinical study

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Christodoulou et al 2015 Journal of Pharmacy and Pharmacology

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Alzheimer's Second Clinical